Detalhe da pesquisa
1.
Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature
; 626(7997): 194-206, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096902
2.
Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
Nature
; 526(7572): 273-276, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416749
3.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Bioorg Med Chem Lett
; 22(17): 5563-8, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858142
4.
High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 4): 404-8, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22505407
5.
Macrocyclic statine-based inhibitors of BACE-1.
Chembiochem
; 8(17): 2078-91, 2007 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17963207
6.
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.
J Mol Biol
; 352(4): 918-31, 2005 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-16125198
7.
Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.
ACS Med Chem Lett
; 6(1): 89-94, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25589937
8.
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
J Med Chem
; 55(14): 6363-74, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22742641
9.
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
J Med Chem
; 55(20): 8827-37, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22984809
10.
Key factors for successful generation of protein-fragment structures requirement on protein, crystals, and technology.
Methods Enzymol
; 493: 61-89, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21371587
11.
Phosphorylation of the human full-length protein kinase Ciota.
J Proteome Res
; 7(7): 2928-35, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18489133